Pulmonary Drug Delivery System

Pulmonary drug delivery is primarily use to treat conditions of the airways, delivering locally acting drugs directly to their site of action. These routes of drug delivery may give the advantages like small amount of drug, less adverse reaction and rapid onset of action. The human respiratory system is complicated organ system these system consist of two reagions conducting airways and respiratory region. The airway further divided in to many folds such as nasal cavity, nasopharynx, oropharynx, larynx, trachea, bronchi, and bronchioles. The respiratory region consists of respiratory, bronchioles, alveolar ducts and alveolar sac. Pulmonary drug delivery may show that many molecule are absorbed through the deep lung in ton the bloodstream naturally with high bioavailability and without the need for enhancer used by other noninvasive route. In these inhalation therapy most common device use such as nebulizer which consist of two types such as Jet nebulizer and Ultrasonic nebulizer, Metered dose inhaler (MDI), and Dry powder inhaler(DPI). Pulmonary drug delivery is used for management of COPD and Asthma only but due to advancement in application nowadays Pulmonary drug delivery is useful to treat Diabetes, angina pectoris, cancer, bone disorders, tuberculosis, migraine acute lung injury and others. We also describe here the various evaluation parameter for pulmonary drug devices. In these review we study the pulmonary disease, different devices use on it, and there application with its evaluation parameter.